' 
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Good
Based on 1 Review
8
Supplement Facts
Serving Size: 4 Capsules
Serving Per Container: 30
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
50 mg
56%
Vitamin D (as D3 from culture of S. cerevisiae)
40 mcg (1,600 IU)
200%
Vitamin K (from culture of S. cerevisiae)
120 mcg
100%
Calcium (naturally occurring from Algae)
1,100 mg
85%
Magnesium (from Algae and Dead Sea minerals)
357 mg
85%
Vitamin K (as K2 MK-7)
50 mcg
+
Strontium (naturally occurring from Algae)
3.8 mg
+
Boron (from Brown Rice Chelate)
3 mg
+
Silica (naturally occurring from Algae)
2.2 mg
+
Vanadium (naturally occurring from Algae)
25 mcg
+
Raw Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus bulgaricus, Lactobacillus plantarum] (500 Million CFU).
64 mg
+
Top Medical Research Studies
9
Vitamin D exhibits antifungal activity
Antifungal activity of vitamin D against Candida albicans in vitro and in vivo.
Highly relevant to yeast infections
We examined the potential of vitamin D as a treatment for yeast infections, specifically targeting the troublesome Candida species. The study employed both in vitro and in vivo methods to assess the antifungal capabilities of vitamin D, revealing promising results in inhibiting the growth of these fungi.
Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.
Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.
These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.
Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.
Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.
These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.
Read More
8
Vitamin D reduces Candida infections
Vitamin D-supplemented yogurt drink reduces Candida infections in a paediatric intensive care unit: a randomised, placebo-controlled clinical trial.
Strong relevance to yeast infection
We investigated the effectiveness of vitamin D in reducing Candida infections in children admitted to the pediatric intensive care unit (PICU). This study included 416 children between the ages of 12 months to 5 years who were receiving broad-spectrum antibiotics. They were divided into two groups: one group received a plain yogurt drink (the placebo), while the other was given yogurt enriched with vitamin D at a daily dose of 300 IU.
Our primary focus was on whether vitamin D could decrease instances of Candida colonization, which we measured using rectal swabs 14 days after enrolling the patients. We also looked at secondary outcomes, including Candida growth in blood and urine. The results showed that the children who received the vitamin D yogurt drink had significantly lower cases of Candida infections, both in urine and blood, compared to those who didn't get the vitamin D.
Moreover, those in the vitamin D group had a shorter average stay in the PICU. However, the rate of mortality was similar between both groups, indicating that while vitamin D supplementation helped reduce infections, it didn't affect patient survival rates. Overall, our findings suggest that vitamin D can be an effective strategy for reducing Candida infections in critically ill children undergoing antibiotic treatment.
Our primary focus was on whether vitamin D could decrease instances of Candida colonization, which we measured using rectal swabs 14 days after enrolling the patients. We also looked at secondary outcomes, including Candida growth in blood and urine. The results showed that the children who received the vitamin D yogurt drink had significantly lower cases of Candida infections, both in urine and blood, compared to those who didn't get the vitamin D.
Moreover, those in the vitamin D group had a shorter average stay in the PICU. However, the rate of mortality was similar between both groups, indicating that while vitamin D supplementation helped reduce infections, it didn't affect patient survival rates. Overall, our findings suggest that vitamin D can be an effective strategy for reducing Candida infections in critically ill children undergoing antibiotic treatment.
Read More
8
Vitamin D's potential against yeast
[Studies on the antimicrobial effect of vitamin D (author's transl)].
Direct relevance to yeast infections
We explored how vitamin D3 could potentially affect yeast infections, particularly caused by Candida albicans. The study revealed that in controlled laboratory conditions, vitamin D3 showed a significant inhibitory effect on various strains of bacteria and fungi, including Staphylococcus aureus, Streptococcus pyogenes, Klebsiella pneumoniae, Escherichia coli, and Candida albicans.
The researchers found that when vitamin D3 was present at a concentration of 50,000 to 90,000 IU/ml, these organisms were either killed or experienced marked growth inhibition. This indicates that vitamin D3 might hold promise as an adjunct treatment for yeast infections, but further research would be necessary to fully understand its effectiveness in real-world scenarios.
Overall, this study sheds light on the potential antimicrobial properties of vitamin D3, highlighting its capacity to fight off certain pathogens, including yeast. However, it’s crucial to continue exploring these findings to confirm their applicability beyond the lab environment.
The researchers found that when vitamin D3 was present at a concentration of 50,000 to 90,000 IU/ml, these organisms were either killed or experienced marked growth inhibition. This indicates that vitamin D3 might hold promise as an adjunct treatment for yeast infections, but further research would be necessary to fully understand its effectiveness in real-world scenarios.
Overall, this study sheds light on the potential antimicrobial properties of vitamin D3, highlighting its capacity to fight off certain pathogens, including yeast. However, it’s crucial to continue exploring these findings to confirm their applicability beyond the lab environment.
Read More
Most Useful Reviews
2.5
Avoid synthetic vitamins
Don't take these vitamins; they're not natural. Many derive their vitamins from feeding the yeast Saccharomyces cerevisiae synthetic vitamins. This poses two issues: those allergic to yeast may react negatively, and the vitamins may not be the best forms of synthetics. It's better to opt for vitamins from the same manufacturer’s MyKind Organics series, which provides genuinely natural options. They could effectively support the treatment of yeast infection.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
- All Researches
9
Vitamin D exhibits antifungal activity
Antifungal activity of vitamin D against Candida albicans in vitro and in vivo.
Highly relevant to yeast infections
We examined the potential of vitamin D as a treatment for yeast infections, specifically targeting the troublesome Candida species. The study employed both in vitro and in vivo methods to assess the antifungal capabilities of vitamin D, revealing promising results in inhibiting the growth of these fungi.
Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.
Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.
These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.
Through various tests, including broth microdilution and solid plate assays, we observed that vitamin D could effectively suppress the growth of Candida albicans and other related species in a dose-dependent manner. Notably, it also played a significant role in hindering the formation of biofilms, which are protective structures that Candida can build, making infections harder to treat.
Our exploration into how vitamin D works revealed it impacts several biological processes, affecting the growth and metabolism of Candida. In an animal model simulating intra-abdominal candidiasis, vitamin D appeared to reduce fungal levels in key organs like the liver and kidneys. This treatment not only lowered the fungal burden but also seemed to calm the inflammation associated with the infection.
These findings suggest that vitamin D could be a valuable addition to existing treatments for yeast infections, offering a novel approach against this stubborn pathogen.
Read More
9
Calcium-based antifungal treatment effective
Joint fluid concentrations of amphotericin B after local application with calcium sulphate-report of 2 cases.
Study details calcium's impact
We delved into the effectiveness of calcium sulfate (CaSO) as a local treatment to enhance the delivery of amphotericin B, a powerful antifungal medication, in managing yeast infections around prosthetic joints. Our focus was on two cases of periprosthetic joint infections caused by Candida species, a type of yeast that can be hard to treat due to its ability to form biofilms and resist traditional systemic antifungal therapies.
Both patients received a combination of local amphotericin B delivered via CaSO and standard antifungal treatments. Remarkably, we observed high local concentrations of amphotericin B in joint fluid, which lasted for several weeks after its application. In one instance, the concentration reached 14.01 mg/L just five days after treatment and stayed above effective levels for 21 days. In the second case, levels reached even higher, hitting 25.77 mg/L.
Importantly, while the treatment ensured that drug levels were above what’s necessary to inhibit the growth of Candida, there were no adverse reactions noted, either locally or systemically. After follow-up periods of 12 and 20 months, both patients showed no signs of relapse, marking a successful eradication of the fungal infections. This study suggests that using CaSO as a carrier for amphotericin B is promising for treating yeast infections in particularly stubborn cases, allowing for sustained antifungal concentrations without the need for additional invasive procedures.
Both patients received a combination of local amphotericin B delivered via CaSO and standard antifungal treatments. Remarkably, we observed high local concentrations of amphotericin B in joint fluid, which lasted for several weeks after its application. In one instance, the concentration reached 14.01 mg/L just five days after treatment and stayed above effective levels for 21 days. In the second case, levels reached even higher, hitting 25.77 mg/L.
Importantly, while the treatment ensured that drug levels were above what’s necessary to inhibit the growth of Candida, there were no adverse reactions noted, either locally or systemically. After follow-up periods of 12 and 20 months, both patients showed no signs of relapse, marking a successful eradication of the fungal infections. This study suggests that using CaSO as a carrier for amphotericin B is promising for treating yeast infections in particularly stubborn cases, allowing for sustained antifungal concentrations without the need for additional invasive procedures.
Read More
8
Vitamin D enhances immune response
Paracoccidioidesbrasiliensis induces IL-32 and is controlled by IL-15/IL-32/vitamin D pathway in vitro.
Key link between vitamin D and immunity
We explored how vitamin D interacts with the immune response to yeast infections, specifically focusing on a systemic fungal disease called paracoccidioidomycosis (PCM). This study examined whether vitamin D could enhance the activity of certain cytokines, notably IL-15 and IL-32, which are known to impact immune function.
Our findings revealed that IL-32 is present in lesions from PCM patients and that it can be induced in peripheral blood mononuclear cells (PBMCs) after exposure to P. brasiliensis antigens. The IL-32γ isoform was primarily expressed, suggesting a specific immune response to the infection. However, while IL-15 strongly stimulated IL-32 production, this increase in fungal control required the presence of high levels of vitamin D.
Notably, P. brasiliensis itself did not significantly induce IL-32 when PBMCs were exposed to intact yeast cells, but it did show a positive effect with heat-killed or sonicated yeast. These insights suggest that vitamin D, in conjunction with IL-15 and IL-32, plays a role in combating fungal infections, emphasizing that specific components from the fungus are needed to activate this immune response.
Overall, our results highlight the potential importance of vitamin D in enhancing immune responses against yeast infections through the IL-15/IL-32 pathway, but further investigations are necessary to fully understand its role.
Our findings revealed that IL-32 is present in lesions from PCM patients and that it can be induced in peripheral blood mononuclear cells (PBMCs) after exposure to P. brasiliensis antigens. The IL-32γ isoform was primarily expressed, suggesting a specific immune response to the infection. However, while IL-15 strongly stimulated IL-32 production, this increase in fungal control required the presence of high levels of vitamin D.
Notably, P. brasiliensis itself did not significantly induce IL-32 when PBMCs were exposed to intact yeast cells, but it did show a positive effect with heat-killed or sonicated yeast. These insights suggest that vitamin D, in conjunction with IL-15 and IL-32, plays a role in combating fungal infections, emphasizing that specific components from the fungus are needed to activate this immune response.
Overall, our results highlight the potential importance of vitamin D in enhancing immune responses against yeast infections through the IL-15/IL-32 pathway, but further investigations are necessary to fully understand its role.
Read More
8
Vitamin D reduces Candida infections
Vitamin D-supplemented yogurt drink reduces Candida infections in a paediatric intensive care unit: a randomised, placebo-controlled clinical trial.
Strong relevance to yeast infection
We investigated the effectiveness of vitamin D in reducing Candida infections in children admitted to the pediatric intensive care unit (PICU). This study included 416 children between the ages of 12 months to 5 years who were receiving broad-spectrum antibiotics. They were divided into two groups: one group received a plain yogurt drink (the placebo), while the other was given yogurt enriched with vitamin D at a daily dose of 300 IU.
Our primary focus was on whether vitamin D could decrease instances of Candida colonization, which we measured using rectal swabs 14 days after enrolling the patients. We also looked at secondary outcomes, including Candida growth in blood and urine. The results showed that the children who received the vitamin D yogurt drink had significantly lower cases of Candida infections, both in urine and blood, compared to those who didn't get the vitamin D.
Moreover, those in the vitamin D group had a shorter average stay in the PICU. However, the rate of mortality was similar between both groups, indicating that while vitamin D supplementation helped reduce infections, it didn't affect patient survival rates. Overall, our findings suggest that vitamin D can be an effective strategy for reducing Candida infections in critically ill children undergoing antibiotic treatment.
Our primary focus was on whether vitamin D could decrease instances of Candida colonization, which we measured using rectal swabs 14 days after enrolling the patients. We also looked at secondary outcomes, including Candida growth in blood and urine. The results showed that the children who received the vitamin D yogurt drink had significantly lower cases of Candida infections, both in urine and blood, compared to those who didn't get the vitamin D.
Moreover, those in the vitamin D group had a shorter average stay in the PICU. However, the rate of mortality was similar between both groups, indicating that while vitamin D supplementation helped reduce infections, it didn't affect patient survival rates. Overall, our findings suggest that vitamin D can be an effective strategy for reducing Candida infections in critically ill children undergoing antibiotic treatment.
Read More
8
Vitamin D modulates yeast infection response
1,25-dihydroxyvitamin D3 modulates cytokine production induced by Candida albicans: impact of seasonal variation of immune responses.
Moderate relevance to vitamin D effects
We set out to understand how vitamin D, specifically a form called 1,25-dihydroxyvitamin D3, influences the immune response to Candida albicans, a common yeast infection. Using peripheral blood mononuclear cells, we stimulated these immune cells with the yeast and vitamin D to observe the effects on cytokine production, which are crucial for regulating immune responses.
Our findings revealed that the presence of vitamin D shifted the immune response towards a more anti-inflammatory profile. This was characterized by a decrease in several inflammatory cytokines, such as IL-6, TNFα, IL-17, and IFNγ, while boosting the production of IL-10, which is known for its anti-inflammatory properties. Interestingly, vitamin D also appeared to suppress the expression of various receptors that normally recognize and respond to the yeast.
We conducted further tests to evaluate how seasonal changes affected these immune responses. It turned out that during summer, when levels of vitamin D in the body are generally higher, the production of some pro-inflammatory cytokines was notably reduced. This suggests that higher levels of vitamin D can indeed modulate immune function against yeast infections.
Overall, our study highlights a potential therapeutic role for vitamin D in managing infections like Candida albicans by promoting an anti-inflammatory immune response. The impact of seasonal variations adds an interesting layer to our understanding of how vitamin D might influence our defenses against infections.
Our findings revealed that the presence of vitamin D shifted the immune response towards a more anti-inflammatory profile. This was characterized by a decrease in several inflammatory cytokines, such as IL-6, TNFα, IL-17, and IFNγ, while boosting the production of IL-10, which is known for its anti-inflammatory properties. Interestingly, vitamin D also appeared to suppress the expression of various receptors that normally recognize and respond to the yeast.
We conducted further tests to evaluate how seasonal changes affected these immune responses. It turned out that during summer, when levels of vitamin D in the body are generally higher, the production of some pro-inflammatory cytokines was notably reduced. This suggests that higher levels of vitamin D can indeed modulate immune function against yeast infections.
Overall, our study highlights a potential therapeutic role for vitamin D in managing infections like Candida albicans by promoting an anti-inflammatory immune response. The impact of seasonal variations adds an interesting layer to our understanding of how vitamin D might influence our defenses against infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8
- All Reviews
- Positive Reviews
- Negative Reviews
2.5
Avoid synthetic vitamins
Don't take these vitamins; they're not natural. Many derive their vitamins from feeding the yeast Saccharomyces cerevisiae synthetic vitamins. This poses two issues: those allergic to yeast may react negatively, and the vitamins may not be the best forms of synthetics. It's better to opt for vitamins from the same manufacturer’s MyKind Organics series, which provides genuinely natural options. They could effectively support the treatment of yeast infection.
Read More
